Castleman’s Disease
MR Ali1, KC Ganguly2, B Ahmed2, SMS Rahman1, SSMI Huda1, H Rashid1 KME Khoda1, M Ashrafuzzaman3, PK Dey4, MSR Khan5
Abstract
Castleman’s Disease is an unusual lymphoproliferative disorder that may mimic lymphoma clinically
and pathologically. It is classified clinically as localized and multicentric types, and pathologically as
hyaline vascular and plasma cell type. It is associated with increased risk of lymphoma and follicular
dendritic cell tumors. The pathogenesis of Castleman’s Disease is still controversial and complex.
Active research is ongoing to highlight more on the Etiopathogenesis of this entity. The aim of this
article is to review the literature on pathogenesis of Castleman’s Disease and to focus on advancement
of treatment of this disease.
Keywords: Castleman’s disease, HHV (Human herpes virus), Kaposi’s sarcoma.